Mucoadhesive polymers are widely used in the design of dosage forms for transmucosal drug delivery to the eye, respiratory, gastrointestinal and reproductive tracts. These routes of drug administration offer a number of advantages including improved drug bioavailability, reduced frequency of administration, and the avoidance for the use of injections.

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Oral health is general health. If the oral cavity is kept healthy, the whole body is always healthy. Bacteria in the oral cavity do not stay in the oral cavity, but rather they travel throughout the body and can induce various diseases. Periodontal pathogens are involved in tooth loss. The number of remaining teeth decreases with age. People with more residual teeth can bite food well and live longer with lower incidence of dementia. There are many viruses in the oral cavity that also cause various diseases. Bacteria and viruses induce and aggravate inflammation, and therefore should be removed from the oral cavity. In the natural world, there are are many as yet undiscovered antiviral, antibacterial and anti-inflammatory substances. These natural substances, as well as chemically modified derivatives, help our oral health and lead us to more fulfilling, high quality lives. This Special Issue, entitled “Biological Efficacy of Natural and Chemically Modified Products against Oral Inflammatory Lesions”, was written by specialists from a diverse variety of fields. It serves to provide readers with up-to-date information on incidence rates in each age group, etiology and treatment of stomatitis, and to investigate the application of such treatments as oral care and cosmetic materials.

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This book represents a guide to the academic, scientific and clinical applications of saliva as a diagnostic fluid. This volume is written by leaders in multiple fields and fulfills a demand for a broad understanding of saliva across a range of disciplines.

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This reprint focuses on the stomatognathic system, an heterogenous anatomic apparatus consisting of different organs which may be affected by pathologies linked to general health conditions. From reciprocal influences between periodontitis and diabetes to multiorgan pathologies such as lichen planus and oral mucosae/salivary gland cancer, novel therapeutic approaches and the best clinical practices have been studied by authors from around the world, with a special focus on relations with systemic conditions. As one of the events mainly impacting healthcare worldwide in recent years, the effects of COVID-19 on oral potentially malignant disorders (OPMD) will also be discussed.

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